Quanterix Expands Menu of Ultra-Sensitive Neurology Assays with Simoa® P-Tau181 V2 Kit for Improved Detection and Study of Alzheimer’s Disease
Preliminary research demonstrates the biomarker’s revolutionary potential to empower accessible and scalable blood testing for Alzheimer’s disease;
“Biomarkers continue to play an invaluable role in understanding how neurological diseases manifest, progress and respond to treatment,” said
While deaths associated with other pervasive diseases such as heart disease have declined between 2000 and 2018, Alzheimer’s disease-related deaths have increased by 146 percent, according to the Alzheimer’s Association. Importantly, there is no objective test to diagnose the disorder, leading many physicians to rely solely on subjective cognitive assessments. As a result, many patients are not diagnosed until late in the disease’s progression, after symptoms of cognitive decline, such as memory loss, begin to present. Even then, the disease can often be misdiagnosed for another neurodegenerative condition, such as frontotemporal dementia (FTD).
For years, researchers have studied the utility of biomarkers for understanding, detecting and monitoring Alzheimer’s disease. These efforts have been accelerated in large part by the PPH network, which has grown into a global epicenter for biomarker-enabled innovations to not only detect and treat, but ultimately, prevent disease. Resulting studies demonstrate the vast utility of proteins such as total tau and Nf-L. Researchers, doctors and pharmaceutical companies are now harnessing these biomarkers to see the disease earlier, monitor its progression and inform clinical decision making more effectively, and assess the viability of experimental therapies. Quanterix’ ultra-sensitive immunoassay technology, Simoa, which empowers single- and multi-plex detection of key biomarkers with 1000 times greater sensitivity than competing enzyme-linked immunosorbent assay (ELISA) solutions, is the driving technology behind much of this research. Among the most notable is a 2019 Nature Medicine paper that used Simoa to see signs of Alzheimer’s disease 16 years before symptoms through the high-definition detection of Nf-L. The technology has powered hundreds of similarly peer-reviewed journals over the years that demonstrate the potential for blood-based detection of the disease with equal or greater sensitivity as compared to CSF or PET biomarkers. Collectively, these studies create an influential body of research that advances the preventative care paradigm envisioned by PPH at its inception by supporting the utility of a non-invasive and easily administered blood test to detect Alzheimer’s disease before symptoms.
Today, emerging research suggests that p-tau181 could hold even greater diagnostic promise for Alzheimer’s disease, as it has proven capable of differentiating the condition from other forms of dementia with greater specificity than total tau. Leaders in the field of neurodegenerative disease research, such as the authors of The Lancet Neurology paper Professors
The latest installment of the PPH Think Tank series of webinars, entitled “Novel p-tau181 Blood Immunoassay and the Future of Alzheimer’s
“We’re on the cusp of what could be an incredible new era for Alzheimer’s patients and those with a genetic predisposition to the disease,” said Zetterberg. “The ability to see dementia asymptomatically and moreover conclusively distinguish it as Alzheimer’s disease-induced could forever change the face of this condition. P-tau181 shows immense promise in this regard, which is augmented considerably when harnessed by a leader in detection like Quanterix.”
“Early findings from our work with p-tau181 are very encouraging,” said Blennow. “The biomarker is proving to be an exceptional new tool in our arsenal against Alzheimer’s disease. While CSF p-tau181 has been recognized as a highly valuable biomarker in Alzheimer’s disease pathology, the greater clinical benefit will come from our ability to effectively harness the marker in blood. The unprecedented specificity of p-tau181 paired with a highly sensitive technology like Simoa promises to broaden our knowledge of this devastating disease considerably, with monumental implications for patients and caregivers.”
To register for the webinar, click here.
To learn more about how you can take advantage of our early access program for p-tau181 through the
For more about Quanterix’ Simoa® technology, visit https://www.quanterix.com/Simoa-bead-technology.
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