<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:b1ae735b-90ad-489e-ad42-e14bfe1dd055,g:4c7969f9-f7cb-4ba1-b121-29cc8b91932c-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:qtrx="http://www.quanterix.com/20251231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.quanterix.com/20251231">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2025" schemaLocation="https://xbrl.sec.gov/country/2025/country-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/cyd-af-sub/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-af-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/stpr/2025" schemaLocation="https://xbrl.sec.gov/stpr/2025/stpr-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qtrx-20251231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qtrx-20251231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qtrx-20251231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="qtrx-20251231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.quanterix.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AuditInformation" roleURI="http://www.quanterix.com/role/AuditInformation">
        <link:definition>0000002 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETS" roleURI="http://www.quanterix.com/role/CONSOLIDATEDBALANCESHEETS">
        <link:definition>9952151 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETSParenthetical" roleURI="http://www.quanterix.com/role/CONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>9952152 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFOPERATIONS" roleURI="http://www.quanterix.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS">
        <link:definition>9952153 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS" roleURI="http://www.quanterix.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVELOSS">
        <link:definition>9952154 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY" roleURI="http://www.quanterix.com/role/CONSOLIDATEDSTATEMENTSOFSTOCKHOLDERSEQUITY">
        <link:definition>9952155 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTOFCASHFLOWS" roleURI="http://www.quanterix.com/role/CONSOLIDATEDSTATEMENTOFCASHFLOWS">
        <link:definition>9952156 - Statement - CONSOLIDATED STATEMENT OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OrganizationandNatureofBusiness" roleURI="http://www.quanterix.com/role/OrganizationandNatureofBusiness">
        <link:definition>9952157 - Disclosure - Organization and Nature of Business</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPolicies" roleURI="http://www.quanterix.com/role/SignificantAccountingPolicies">
        <link:definition>9952158 - Disclosure - Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Acquisitions" roleURI="http://www.quanterix.com/role/Acquisitions">
        <link:definition>9952159 - Disclosure - Acquisitions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssets" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssets">
        <link:definition>9952160 - Disclosure - Goodwill &amp; Intangible Assets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueandRelatedMatters" roleURI="http://www.quanterix.com/role/RevenueandRelatedMatters">
        <link:definition>9952161 - Disclosure - Revenue and Related Matters</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AllowanceforCreditLosses" roleURI="http://www.quanterix.com/role/AllowanceforCreditLosses">
        <link:definition>9952162 - Disclosure - Allowance for Credit Losses</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecurities" roleURI="http://www.quanterix.com/role/MarketableSecurities">
        <link:definition>9952163 - Disclosure - Marketable Securities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueofFinancialInstruments" roleURI="http://www.quanterix.com/role/FairValueofFinancialInstruments">
        <link:definition>9952164 - Disclosure - Fair Value of Financial Instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Inventory" roleURI="http://www.quanterix.com/role/Inventory">
        <link:definition>9952165 - Disclosure - Inventory</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipment" roleURI="http://www.quanterix.com/role/PropertyandEquipment">
        <link:definition>9952166 - Disclosure - Property and Equipment</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpensesandOtherCurrentLiabilities" roleURI="http://www.quanterix.com/role/AccruedExpensesandOtherCurrentLiabilities">
        <link:definition>9952167 - Disclosure - Accrued Expenses and Other Current Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensation" roleURI="http://www.quanterix.com/role/StockBasedCompensation">
        <link:definition>9952168 - Disclosure - Stock-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShare" roleURI="http://www.quanterix.com/role/NetLossPerShare">
        <link:definition>9952169 - Disclosure - Net Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.quanterix.com/role/IncomeTaxes">
        <link:definition>9952170 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Leases" roleURI="http://www.quanterix.com/role/Leases">
        <link:definition>9952171 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.quanterix.com/role/CommitmentsandContingencies">
        <link:definition>9952172 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyTransactions" roleURI="http://www.quanterix.com/role/RelatedPartyTransactions">
        <link:definition>9952173 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReporting" roleURI="http://www.quanterix.com/role/SegmentReporting">
        <link:definition>9952174 - Disclosure - Segment Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Restructuring" roleURI="http://www.quanterix.com/role/Restructuring">
        <link:definition>9952175 - Disclosure - Restructuring</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlans" roleURI="http://www.quanterix.com/role/EmployeeBenefitPlans">
        <link:definition>9952176 - Disclosure - Employee Benefit Plans</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEvents" roleURI="http://www.quanterix.com/role/SubsequentEvents">
        <link:definition>9952177 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPoliciesPolicies" roleURI="http://www.quanterix.com/role/SignificantAccountingPoliciesPolicies">
        <link:definition>9955511 - Disclosure - Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPoliciesTables" roleURI="http://www.quanterix.com/role/SignificantAccountingPoliciesTables">
        <link:definition>9955512 - Disclosure - Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsTables" roleURI="http://www.quanterix.com/role/AcquisitionsTables">
        <link:definition>9955513 - Disclosure - Acquisitions (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsTables" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsTables">
        <link:definition>9955514 - Disclosure - Goodwill &amp; Intangible Assets (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueandRelatedMattersTables" roleURI="http://www.quanterix.com/role/RevenueandRelatedMattersTables">
        <link:definition>9955515 - Disclosure - Revenue and Related Matters (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AllowanceforCreditLossesTables" roleURI="http://www.quanterix.com/role/AllowanceforCreditLossesTables">
        <link:definition>9955516 - Disclosure - Allowance for Credit Losses (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesTables" roleURI="http://www.quanterix.com/role/MarketableSecuritiesTables">
        <link:definition>9955517 - Disclosure - Marketable Securities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueofFinancialInstrumentsTables" roleURI="http://www.quanterix.com/role/FairValueofFinancialInstrumentsTables">
        <link:definition>9955518 - Disclosure - Fair Value of Financial Instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoryTables" roleURI="http://www.quanterix.com/role/InventoryTables">
        <link:definition>9955519 - Disclosure - Inventory (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentTables" roleURI="http://www.quanterix.com/role/PropertyandEquipmentTables">
        <link:definition>9955520 - Disclosure - Property and Equipment (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpensesandOtherCurrentLiabilitiesTables" roleURI="http://www.quanterix.com/role/AccruedExpensesandOtherCurrentLiabilitiesTables">
        <link:definition>9955521 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationTables" roleURI="http://www.quanterix.com/role/StockBasedCompensationTables">
        <link:definition>9955522 - Disclosure - Stock-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShareTables" roleURI="http://www.quanterix.com/role/NetLossPerShareTables">
        <link:definition>9955523 - Disclosure - Net Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesTables" roleURI="http://www.quanterix.com/role/IncomeTaxesTables">
        <link:definition>9955524 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesTables" roleURI="http://www.quanterix.com/role/LeasesTables">
        <link:definition>9955525 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingTables" roleURI="http://www.quanterix.com/role/SegmentReportingTables">
        <link:definition>9955526 - Disclosure - Segment Reporting (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OrganizationandNatureofBusinessDetails" roleURI="http://www.quanterix.com/role/OrganizationandNatureofBusinessDetails">
        <link:definition>9955527 - Disclosure - Organization and Nature of Business (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPoliciesNarrativeDetails" roleURI="http://www.quanterix.com/role/SignificantAccountingPoliciesNarrativeDetails">
        <link:definition>9955528 - Disclosure - Significant Accounting Policies - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPoliciesScheduleofCashandCashEquivalentsDetails" roleURI="http://www.quanterix.com/role/SignificantAccountingPoliciesScheduleofCashandCashEquivalentsDetails">
        <link:definition>9955529 - Disclosure - Significant Accounting Policies - Schedule of Cash and Cash Equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantAccountingPoliciesScheduleofRestrictedCashDetails" roleURI="http://www.quanterix.com/role/SignificantAccountingPoliciesScheduleofRestrictedCashDetails">
        <link:definition>9955530 - Disclosure - Significant Accounting Policies - Schedule of Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantaccountingpoliciesScheduleofPropertyandEquipmentDetails" roleURI="http://www.quanterix.com/role/SignificantaccountingpoliciesScheduleofPropertyandEquipmentDetails">
        <link:definition>9955531 - Disclosure - Significant accounting policies - Schedule of Property and Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsScheduleofFairValueoftheAggregateConsiderationPaidorPayableDetails" roleURI="http://www.quanterix.com/role/AcquisitionsScheduleofFairValueoftheAggregateConsiderationPaidorPayableDetails">
        <link:definition>9955532 - Disclosure - Acquisitions - Schedule of Fair Value of the Aggregate Consideration Paid or Payable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsScheduleOfPreliminaryAllocationOfThePurchasePriceDetails" roleURI="http://www.quanterix.com/role/AcquisitionsScheduleOfPreliminaryAllocationOfThePurchasePriceDetails">
        <link:definition>9955533 - Disclosure - Acquisitions - Schedule Of Preliminary Allocation Of The Purchase Price (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsScheduleOfBusinessCombinationIntangibleAssetAcquiredDetails" roleURI="http://www.quanterix.com/role/AcquisitionsScheduleOfBusinessCombinationIntangibleAssetAcquiredDetails">
        <link:definition>9955534 - Disclosure - Acquisitions - Schedule Of Business Combination, Intangible Asset, Acquired (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsNarrativeDetails" roleURI="http://www.quanterix.com/role/AcquisitionsNarrativeDetails">
        <link:definition>9955535 - Disclosure - Acquisitions - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsScheduleofUnauditedProFormaFinancialInformationDetails" roleURI="http://www.quanterix.com/role/AcquisitionsScheduleofUnauditedProFormaFinancialInformationDetails">
        <link:definition>9955536 - Disclosure - Acquisitions - Schedule of Unaudited Pro Forma Financial Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AcquisitionsScheduleofFairValueoftheAggregateConsiderationPaidorPayableDetails_1" roleURI="http://www.quanterix.com/role/AcquisitionsScheduleofFairValueoftheAggregateConsiderationPaidorPayableDetails_1">
        <link:definition>9955537 - Disclosure - Acquisitions - Schedule of Fair Value of the Aggregate Consideration Paid or Payable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsNarrativeDetails" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsNarrativeDetails">
        <link:definition>9955538 - Disclosure - Goodwill &amp; Intangible Assets - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsScheduleofGoodwillDetails" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsScheduleofGoodwillDetails">
        <link:definition>9955539 - Disclosure - Goodwill &amp; Intangible Assets - Schedule of Goodwill (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsScheduleofIntangibleAssetsDetails" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsScheduleofIntangibleAssetsDetails">
        <link:definition>9955540 - Disclosure - Goodwill &amp; Intangible Assets - Schedule of Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsScheduleofIntangibleAssetsDetails_1" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsScheduleofIntangibleAssetsDetails_1">
        <link:definition>9955540 - Disclosure - Goodwill &amp; Intangible Assets - Schedule of Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="GoodwillIntangibleAssetsScheduleofFutureEstimatedAmortizationExpenseofAcquiredIntangibleAssetsDetails" roleURI="http://www.quanterix.com/role/GoodwillIntangibleAssetsScheduleofFutureEstimatedAmortizationExpenseofAcquiredIntangibleAssetsDetails">
        <link:definition>9955541 - Disclosure - Goodwill &amp; Intangible Assets - Schedule of Future Estimated Amortization Expense of Acquired Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueandRelatedMattersScheduleofDisaggregatedrevenueDetails" roleURI="http://www.quanterix.com/role/RevenueandRelatedMattersScheduleofDisaggregatedrevenueDetails">
        <link:definition>9955542 - Disclosure - Revenue and Related Matters - Schedule of Disaggregated revenue (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueandRelatedMattersNarrativeDetails" roleURI="http://www.quanterix.com/role/RevenueandRelatedMattersNarrativeDetails">
        <link:definition>9955543 - Disclosure - Revenue and Related Matters - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenueandRelatedMattersNarrativeDetails_1" roleURI="http://www.quanterix.com/role/RevenueandRelatedMattersNarrativeDetails_1">
        <link:definition>9955543 - Disclosure - Revenue and Related Matters - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AllowanceforCreditLossesDetails" roleURI="http://www.quanterix.com/role/AllowanceforCreditLossesDetails">
        <link:definition>9955544 - Disclosure - Allowance for Credit Losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesScheduleofAmortizedCostGrossUnrealizedGainsGrossUnrealizedLossesandFairValueDetails" roleURI="http://www.quanterix.com/role/MarketableSecuritiesScheduleofAmortizedCostGrossUnrealizedGainsGrossUnrealizedLossesandFairValueDetails">
        <link:definition>9955545 - Disclosure - Marketable Securities - Schedule of Amortized Cost, Gross Unrealized Gains, Gross Unrealized Losses, and Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesScheduleofFairValueandGrossUnrealizedLossesDetails" roleURI="http://www.quanterix.com/role/MarketableSecuritiesScheduleofFairValueandGrossUnrealizedLossesDetails">
        <link:definition>9955546 - Disclosure - Marketable Securities - Schedule of Fair Value and Gross Unrealized Losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesNarrativeDetails" roleURI="http://www.quanterix.com/role/MarketableSecuritiesNarrativeDetails">
        <link:definition>9955547 - Disclosure - Marketable Securities - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="MarketableSecuritiesScheduleofContractualMaturitiesofMarketableSecuritiesDetails" roleURI="http://www.quanterix.com/role/MarketableSecuritiesScheduleofContractualMaturitiesofMarketableSecuritiesDetails">
        <link:definition>9955548 - Disclosure - Marketable Securities - Schedule of Contractual Maturities of Marketable Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueofFinancialInstrumentsScheduleofFairValueofFinancialAssetsandLiabilitiesDetails" roleURI="http://www.quanterix.com/role/FairValueofFinancialInstrumentsScheduleofFairValueofFinancialAssetsandLiabilitiesDetails">
        <link:definition>9955549 - Disclosure - Fair Value of Financial Instruments - Schedule of Fair Value of Financial Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueofFinancialInstrumentsScheduleofFairValueMeasuredonRecurringBasisDetails" roleURI="http://www.quanterix.com/role/FairValueofFinancialInstrumentsScheduleofFairValueMeasuredonRecurringBasisDetails">
        <link:definition>9955550 - Disclosure - Fair Value of Financial Instruments - Schedule of Fair Value Measured on Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueofFinancialInstrumentsNarrativeDetails" roleURI="http://www.quanterix.com/role/FairValueofFinancialInstrumentsNarrativeDetails">
        <link:definition>9955551 - Disclosure - Fair Value of Financial Instruments - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InventoryDetails" roleURI="http://www.quanterix.com/role/InventoryDetails">
        <link:definition>9955552 - Disclosure - Inventory (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentScheduleofPropertyandequipmentDetails" roleURI="http://www.quanterix.com/role/PropertyandEquipmentScheduleofPropertyandequipmentDetails">
        <link:definition>9955553 - Disclosure - Property and Equipment - Schedule of Property and equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="PropertyandEquipmentNarrativeDetails" roleURI="http://www.quanterix.com/role/PropertyandEquipmentNarrativeDetails">
        <link:definition>9955554 - Disclosure - Property and Equipment - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AccruedExpensesandOtherCurrentLiabilitiesDetails" roleURI="http://www.quanterix.com/role/AccruedExpensesandOtherCurrentLiabilitiesDetails">
        <link:definition>9955555 - Disclosure - Accrued Expenses and Other Current Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationNarrativeDetails" roleURI="http://www.quanterix.com/role/StockBasedCompensationNarrativeDetails">
        <link:definition>9955556 - Disclosure - Stock-Based Compensation - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationScheduleofStockOptionsDetails" roleURI="http://www.quanterix.com/role/StockBasedCompensationScheduleofStockOptionsDetails">
        <link:definition>9955557 - Disclosure - Stock-Based Compensation - Schedule of Stock Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationScheduleofRestrictedStockUnitsDetails" roleURI="http://www.quanterix.com/role/StockBasedCompensationScheduleofRestrictedStockUnitsDetails">
        <link:definition>9955558 - Disclosure - Stock-Based Compensation - Schedule of Restricted Stock Units (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationScheduleofShareBasedCompensationExpenseDetails" roleURI="http://www.quanterix.com/role/StockBasedCompensationScheduleofShareBasedCompensationExpenseDetails">
        <link:definition>9955559 - Disclosure - Stock-Based Compensation - Schedule of Share-Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationScheduleofBlackScholesvaluationmodelAssumptionsDetails" roleURI="http://www.quanterix.com/role/StockBasedCompensationScheduleofBlackScholesvaluationmodelAssumptionsDetails">
        <link:definition>9955560 - Disclosure - Stock-Based Compensation - Schedule of Black-Scholes valuation model Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShareScheduleofBasicandDilutedDetails" roleURI="http://www.quanterix.com/role/NetLossPerShareScheduleofBasicandDilutedDetails">
        <link:definition>9955561 - Disclosure - Net Loss Per Share - Schedule of Basic and Diluted (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NetLossPerShareScheduleofCommonshareequivalentshavebeenexcludedfromthecalculationofdilutednetlosspershareDetails" roleURI="http://www.quanterix.com/role/NetLossPerShareScheduleofCommonshareequivalentshavebeenexcludedfromthecalculationofdilutednetlosspershareDetails">
        <link:definition>9955562 - Disclosure - Net Loss Per Share - Schedule of Common share equivalents have been excluded from the calculation of diluted net loss per share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofComponentsoflossbeforeincometaxesDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofComponentsoflossbeforeincometaxesDetails">
        <link:definition>9955563 - Disclosure - Income taxes - Schedule of Components of loss before income taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofProvisionforincometaxbenefitDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofProvisionforincometaxbenefitDetails">
        <link:definition>9955564 - Disclosure - Income taxes - Schedule of Provision for income tax benefit (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofReconciliationofFederalStatutoryIncomeTaxRatetoEffectiveTaxRateDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofReconciliationofFederalStatutoryIncomeTaxRatetoEffectiveTaxRateDetails">
        <link:definition>9955565 - Disclosure - Income taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Tax Rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9955566 - Disclosure - Income taxes - Schedule of Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofValuationAllowanceDeferredTaxDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofValuationAllowanceDeferredTaxDetails">
        <link:definition>9955567 - Disclosure - Income taxes - Schedule of Valuation Allowance Deferred Tax (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesNarrativeDetails" roleURI="http://www.quanterix.com/role/IncometaxesNarrativeDetails">
        <link:definition>9955568 - Disclosure - Income taxes - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxesScheduleofCashFlowSupplementalDisclosuresDetails" roleURI="http://www.quanterix.com/role/IncometaxesScheduleofCashFlowSupplementalDisclosuresDetails">
        <link:definition>9955569 - Disclosure - Income taxes - Schedule of Cash Flow, Supplemental Disclosures (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesNarrativeDetails" roleURI="http://www.quanterix.com/role/LeasesNarrativeDetails">
        <link:definition>9955570 - Disclosure - Leases - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesScheduleofLeaseCostDetails" roleURI="http://www.quanterix.com/role/LeasesScheduleofLeaseCostDetails">
        <link:definition>9955571 - Disclosure - Leases - Schedule of Lease Cost (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesScheduleofSupplementalcashflowinformationDetails" roleURI="http://www.quanterix.com/role/LeasesScheduleofSupplementalcashflowinformationDetails">
        <link:definition>9955572 - Disclosure - Leases - Schedule of Supplemental cash flow information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesScheduleofUndiscountedfutureleasepaymentsfornoncancelableoperatingleasesDetails" roleURI="http://www.quanterix.com/role/LeasesScheduleofUndiscountedfutureleasepaymentsfornoncancelableoperatingleasesDetails">
        <link:definition>9955573 - Disclosure - Leases - Schedule of Undiscounted future lease payments for non-cancelable operating leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeasesScheduleofUndiscountedfutureleasepaymentsfornoncancelableoperatingleasesDetails_1" roleURI="http://www.quanterix.com/role/LeasesScheduleofUndiscountedfutureleasepaymentsfornoncancelableoperatingleasesDetails_1">
        <link:definition>9955573 - Disclosure - Leases - Schedule of Undiscounted future lease payments for non-cancelable operating leases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentandContingenciesDetails" roleURI="http://www.quanterix.com/role/CommitmentandContingenciesDetails">
        <link:definition>9955574 - Disclosure - Commitment and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RelatedPartyTransactionsDetails" roleURI="http://www.quanterix.com/role/RelatedPartyTransactionsDetails">
        <link:definition>9955575 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingNarrativeDetails" roleURI="http://www.quanterix.com/role/SegmentReportingNarrativeDetails">
        <link:definition>9955576 - Disclosure - Segment Reporting - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentReportingScheduleofSegmentReportingInformationbySegmentDetails" roleURI="http://www.quanterix.com/role/SegmentReportingScheduleofSegmentReportingInformationbySegmentDetails">
        <link:definition>9955577 - Disclosure - Segment Reporting - Schedule of Segment Reporting Information, by Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RestructuringDetails" roleURI="http://www.quanterix.com/role/RestructuringDetails">
        <link:definition>9955578 - Disclosure - Restructuring (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlansDetails" roleURI="http://www.quanterix.com/role/EmployeeBenefitPlansDetails">
        <link:definition>9955579 - Disclosure - Employee Benefit Plans (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEventsDetails" roleURI="http://www.quanterix.com/role/SubsequentEventsDetails">
        <link:definition>9955580 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="qtrx_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_AccruedExpensesAndOtherLiabilitiesCurrent" abstract="false" name="AccruedExpensesAndOtherLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_ServiceAndOtherRevenueMember" abstract="true" name="ServiceAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_OtherLeaseCosts" abstract="false" name="OtherLeaseCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_NoncashOrPartNoncashAcquisitionEquityConsiderationTransferred" abstract="false" name="NoncashOrPartNoncashAcquisitionEquityConsiderationTransferred" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_AccruedLiabilitiesAndOtherLiabilitiesCurrentAbstract" abstract="true" name="AccruedLiabilitiesAndOtherLiabilitiesCurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_AccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock" abstract="false" name="AccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qtrx_RevenueRecognitionGrantsPolicyTextBlock" abstract="false" name="RevenueRecognitionGrantsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qtrx_ScheduleOfPropertyPlantAndEquipmentUsefulLifeTableTextBlock" abstract="false" name="ScheduleOfPropertyPlantAndEquipmentUsefulLifeTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qtrx_AccruedLiabilitiesAndOtherLiabilitiesCurrentTableTextBlock" abstract="false" name="AccruedLiabilitiesAndOtherLiabilitiesCurrentTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qtrx_LesseeOperatingLeaseCashFlowInformationTableTextBlock" abstract="false" name="LesseeOperatingLeaseCashFlowInformationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="qtrx_CustomerMember" abstract="true" name="CustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_OneCustomerMember" abstract="true" name="OneCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_CustomersOutsideOfUnitedStatesMember" abstract="true" name="CustomersOutsideOfUnitedStatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_PeriodOfPaymentFromCustomers" abstract="false" name="PeriodOfPaymentFromCustomers" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qtrx_NumberOfCustomersWithHighPercentOfTotalRevenue" abstract="false" name="NumberOfCustomersWithHighPercentOfTotalRevenue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qtrx_AkoyaBiosciencesInc.Member" abstract="true" name="AkoyaBiosciencesInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_BusinessCombinationConsiderationTransferredEquityExchangeRatio" abstract="false" name="BusinessCombinationConsiderationTransferredEquityExchangeRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qtrx_BusinessCombinationConsiderationTransferredFairValueOfReplacementEquityAwardsAttributableToPreCombinationService" abstract="false" name="BusinessCombinationConsiderationTransferredFairValueOfReplacementEquityAwardsAttributableToPreCombinationService" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationConsiderationTransferredFractionalSharesPricePerShare" abstract="false" name="BusinessCombinationConsiderationTransferredFractionalSharesPricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="qtrx_BusinessCombinationConsiderationTransferredSettlementOfEarlyTerminationLegalAndPrepaymentFees" abstract="false" name="BusinessCombinationConsiderationTransferredSettlementOfEarlyTerminationLegalAndPrepaymentFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_EmissionInc.Member" abstract="true" name="EmissionInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCashAndCashEquivalents" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentCashAndCashEquivalents" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccountsReceivableNetOfAllowanceForExpectedCreditLosses" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccountsReceivableNetOfAllowanceForExpectedCreditLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedAssetAcquiredPrepaidExpenseAndOtherAsset" abstract="false" name="BusinessCombinationRecognizedAssetAcquiredPrepaidExpenseAndOtherAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentPrepaidExpenseAndOtherAsset" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentPrepaidExpenseAndOtherAsset" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedAssetAcquiredOperatingLeasesRightOfUseAssetsNet" abstract="false" name="BusinessCombinationRecognizedAssetAcquiredOperatingLeasesRightOfUseAssetsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOperatingLeasesRightOfUseAssetsNet" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOperatingLeasesRightOfUseAssetsNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedAssetAcquiredFinanceLeasesRightOfUseAssetsNet" abstract="false" name="BusinessCombinationRecognizedAssetAcquiredFinanceLeasesRightOfUseAssetsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinanceLeasesRightOfUseAssetsNet" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinanceLeasesRightOfUseAssetsNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedAssetAcquiredAssetsIncludingGoodwill" abstract="false" name="BusinessCombinationRecognizedAssetAcquiredAssetsIncludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAssets" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccountsPayable" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccountsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedLiabilityAssumedAccruedExpensesAndOtherLiabilities" abstract="false" name="BusinessCombinationRecognizedLiabilityAssumedAccruedExpensesAndOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpensesAndOtherLiabilities" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentAccruedExpensesAndOtherLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredRevenue" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentDeferredRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilities" abstract="false" name="BusinessCombinationRecognizedLiabilityAssumedOperatingLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOperatingLeaseLiabilities" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentOperatingLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationRecognizedLiabilityAssumedFinanceLeaseLiabilities" abstract="false" name="BusinessCombinationRecognizedLiabilityAssumedFinanceLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinanceLeaseLiabilities" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentFinanceLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentLiabilities" abstract="false" name="BusinessCombinationProvisionalInformationInitialAccountingIncompleteAdjustmentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_Earnout1Member" abstract="true" name="Earnout1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_Earnout2Member" abstract="true" name="Earnout2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ContractWithCustomerLiabilityUnfavorableTerms" abstract="false" name="ContractWithCustomerLiabilityUnfavorableTerms" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_ContractWithCustomerLiabilityNonCashRevenueRecognized" abstract="false" name="ContractWithCustomerLiabilityNonCashRevenueRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_NumberOfContingentConsiderationArrangements" abstract="false" name="NumberOfContingentConsiderationArrangements" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="qtrx_BusinessCombinationContingentConsiderationPerformancePeriod" abstract="false" name="BusinessCombinationContingentConsiderationPerformancePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qtrx_OptionContractIndexedToEquityPeriod" abstract="false" name="OptionContractIndexedToEquityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qtrx_OptionIndexedToIssuersEquityRedemptionRequirementRevenueThreshold" abstract="false" name="OptionIndexedToIssuersEquityRedemptionRequirementRevenueThreshold" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_GoodwillImpairmentLossStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" abstract="false" name="GoodwillImpairmentLossStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_KnowHowMember" abstract="true" name="KnowHowMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_FiniteLivedIntangibleAssetsCumulativeTranslationAdjustments" abstract="false" name="FiniteLivedIntangibleAssetsCumulativeTranslationAdjustments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_FiniteLivedIntangibleAssetsNetIncludingCumulativeTranslationAdjustments" abstract="false" name="FiniteLivedIntangibleAssetsNetIncludingCumulativeTranslationAdjustments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_InstrumentProductsMember" abstract="true" name="InstrumentProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ConsumableAndOtherProductsMember" abstract="true" name="ConsumableAndOtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_SimoaProductRevenueMember" abstract="true" name="SimoaProductRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_SpatialProductRevenueMember" abstract="true" name="SpatialProductRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ResearchServicesMember" abstract="true" name="ResearchServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ServiceTypeWarrantiesMember" abstract="true" name="ServiceTypeWarrantiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_OtherServicesMember" abstract="true" name="OtherServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_SimoaServiceAndOtherRevenueMember" abstract="true" name="SimoaServiceAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_SpatialServiceAndOtherRevenueMember" abstract="true" name="SpatialServiceAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_UndeliveredLicensesOfIntellectualPropertyMember" abstract="true" name="UndeliveredLicensesOfIntellectualPropertyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_AccountsReceivableAllowanceForCreditLossAcquiredThroughAcquisition" abstract="false" name="AccountsReceivableAllowanceForCreditLossAcquiredThroughAcquisition" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_AccountsReceivableAllowanceForCreditLossWriteOffRecovery" abstract="false" name="AccountsReceivableAllowanceForCreditLossWriteOffRecovery" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DebtSecuritiesAvailableForSaleMaturityAllocatedAndSingleMaturityDateRollingBetweenOneToTwoYearsAmortizedCost" abstract="false" name="DebtSecuritiesAvailableForSaleMaturityAllocatedAndSingleMaturityDateRollingBetweenOneToTwoYearsAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DebtSecuritiesAvailableForSaleMaturityAllocatedAndSingleMaturityDateRollingWithinOneToTwoYearsFairValue" abstract="false" name="DebtSecuritiesAvailableForSaleMaturityAllocatedAndSingleMaturityDateRollingWithinOneToTwoYearsFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_PKILicenseMember" abstract="true" name="PKILicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_FairValueRecurringBasisUnobservableInputReconciliationLiabilityGainLossStatementOfIncomeExtensibleListNotDisclosedFlag" abstract="false" name="FairValueRecurringBasisUnobservableInputReconciliationLiabilityGainLossStatementOfIncomeExtensibleListNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_BusinessCombinationContingentConsiderationPaymentPeriod" abstract="false" name="BusinessCombinationContingentConsiderationPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="qtrx_LaboratoryAndManufacturingEquipmentMember" abstract="true" name="LaboratoryAndManufacturingEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_DemoInventoryMember" abstract="true" name="DemoInventoryMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ComputersAndSoftwareMember" abstract="true" name="ComputersAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_AccruedAcquisitionRelatedHoldbackCurrent" abstract="false" name="AccruedAcquisitionRelatedHoldbackCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_ContractWithCustomerOffMarketLiabilityCurrent" abstract="false" name="ContractWithCustomerOffMarketLiabilityCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_AccruedOtherCost" abstract="false" name="AccruedOtherCost" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_EmployeeDirectorAndConsultant2017EquityIncentivePlanMember" abstract="true" name="EmployeeDirectorAndConsultant2017EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_EmployeeStockPurchasePlan2017Member" abstract="true" name="EmployeeStockPurchasePlan2017Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_InducementPlanMember" abstract="true" name="InducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_A2021AkoyaEquityIncentivePlanMember" abstract="true" name="A2021AkoyaEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_AkoyaInducementPlanMember" abstract="true" name="AkoyaInducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_A2025InducementPlanMember" abstract="true" name="A2025InducementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_RestrictedStockUnitsAndStockOptionsMember" abstract="true" name="RestrictedStockUnitsAndStockOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEvergreenProvisionAnnualIncreasePercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEvergreenProvisionAnnualIncreasePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesOutstandingShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesOutstandingShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForIssuanceIncreaseNumberShares" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForIssuanceIncreaseNumberShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedThroughAcquisition" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedThroughAcquisition" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedExpectedToConvertNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedExpectedToConvertNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedThroughAcquisitionWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAssumedThroughAcquisitionWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="qtrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToConvertWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToConvertWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="qtrx_CostOfProductRevenueMember" abstract="true" name="CostOfProductRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_CostOfServiceAndOtherRevenueMember" abstract="true" name="CostOfServiceAndOtherRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_EmployeeStockPurchasePlanAwardsMember" abstract="true" name="EmployeeStockPurchasePlanAwardsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_CommonStockAndRSUsMember" abstract="true" name="CommonStockAndRSUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_EstimatedEsppPurchasesMember" abstract="true" name="EstimatedEsppPurchasesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLimitationOnExecutiveCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLimitationOnExecutiveCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCostsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qtrx_EffectiveIncomeTaxRateReconciliationPermanentItemsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationPermanentItemsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qtrx_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLimitationOnExecutiveCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseLimitationOnExecutiveCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="qtrx_DeferredTaxAssetsAmortization" abstract="false" name="DeferredTaxAssetsAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DeferredTaxAssetsLeaseLiability" abstract="false" name="DeferredTaxAssetsLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DeferredTaxAssetsNondeductibleInterestCarryforward" abstract="false" name="DeferredTaxAssetsNondeductibleInterestCarryforward" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DeferredTaxLiabilitiesRightOfUseAsset" abstract="false" name="DeferredTaxLiabilitiesRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DeferredTaxLiabilitiesDepreciationAndAmortization" abstract="false" name="DeferredTaxLiabilitiesDepreciationAndAmortization" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_DeferredTaxAssetValuationAllowanceRollForward" abstract="true" name="DeferredTaxAssetValuationAllowanceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_IncomeTaxDisclosureTable" abstract="true" name="IncomeTaxDisclosureTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_ThroughTaxYear2037Member" abstract="true" name="ThroughTaxYear2037Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ThroughTaxYear2045Member" abstract="true" name="ThroughTaxYear2045Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ThroughTaxYear2040Member" abstract="true" name="ThroughTaxYear2040Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_IncomeTaxDisclosureLineItems" abstract="true" name="IncomeTaxDisclosureLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="qtrx_OperatingLossCarryforwardsSubjectToExpire" abstract="false" name="OperatingLossCarryforwardsSubjectToExpire" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_OperatingLossCarryforwardsWithoutExpiration" abstract="false" name="OperatingLossCarryforwardsWithoutExpiration" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_ImpairmentChargesRelatedROUAssetsAndLeaseholdImprovements" abstract="false" name="ImpairmentChargesRelatedROUAssetsAndLeaseholdImprovements" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_CashPaidForAmountsIncludedInTheMeasurementOfOperatingLeaseLiabilities" abstract="false" name="CashPaidForAmountsIncludedInTheMeasurementOfOperatingLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="qtrx_HarvardUniversityMember" abstract="true" name="HarvardUniversityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_TuftsUniversityMember" abstract="true" name="TuftsUniversityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_LicenseAgreementsMember" abstract="true" name="LicenseAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_BiopharmaceuticalCustomerMember" abstract="true" name="BiopharmaceuticalCustomerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="qtrx_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
