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Share-based compensation expense (Details) link:presentationLink link:calculationLink link:definitionLink 40903 - Disclosure - Warrants, stock-based compensation, stock options, restricted stock and restricted stock units - Stock-based award plans (Details) link:presentationLink link:calculationLink link:definitionLink 40904 - Disclosure - Warrants, stock-based compensation, stock options, restricted stock and restricted stock units - Stock options (Details) link:presentationLink link:calculationLink link:definitionLink 40905 - Disclosure - Warrants, stock-based compensation, stock options, restricted stock and restricted stock units - Restricted stock (Details) link:presentationLink link:calculationLink link:definitionLink 40906 - Disclosure - Warrants, stock-based compensation, stock options, restricted stock and restricted stock units - Restricted stock units (Details) link:presentationLink link:calculationLink link:definitionLink 41001 - Disclosure - Leases (Details) link:presentationLink link:calculationLink link:definitionLink 41101 - Disclosure - Commitments and contingencies - License agreements and Lease commitments (Details) link:presentationLink link:calculationLink link:definitionLink 41102 - Disclosure - Commitments and contingencies - Development and supply agreement and Legal contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 41201 - Disclosure - Notes payable (Details) link:presentationLink link:calculationLink link:definitionLink 41301 - Disclosure - Collaboration and license arrangements (Details) link:presentationLink link:calculationLink link:definitionLink 41401 - Disclosure - Employee benefit plans (Details) link:presentationLink link:calculationLink link:definitionLink 41601 - Disclosure - Underwritten public offerings (Details) link:presentationLink link:calculationLink link:definitionLink 41701 - Disclosure - Related party transactions (Details) link:presentationLink link:calculationLink link:definitionLink 41801 - Disclosure - Accumulated other comprehensive income (loss) (Details) link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Allowance for Credit Losses link:presentationLink link:calculationLink link:definitionLink 11001 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 11401 - Disclosure - Employee benefit plans link:presentationLink link:calculationLink link:definitionLink 11701 - Disclosure - Related party transactions link:presentationLink link:calculationLink link:definitionLink 11801 - Disclosure - Accumulated other comprehensive income (loss) link:presentationLink link:calculationLink link:definitionLink 11901 - Disclosure - Subsequent events link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Allowance for Credit Losses (Tables) link:presentationLink link:calculationLink link:definitionLink 31003 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 31803 - Disclosure - Accumulated other comprehensive income (loss) (Tables) link:presentationLink link:calculationLink link:definitionLink 40306 - Disclosure - Revenue recognition - Practical expedients (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Allowance for Credit Losses (Details) link:presentationLink link:calculationLink link:definitionLink