Quanterix’ Simoa Technology Powers New Insights into COVID-19 Immune Response and Reveals Indicators of Disease Severity
Findings from newly published research demonstrate promise of ultra-sensitive biomarker technology to identify and define high-risk populations through quantification of interferon (IFN) type I
“Through our collaborations with
An estimated one-in-five patients will develop a severe or critical form of COVID-19. Experts believe this can be traced to an overproduction of immune molecules, known as a cytokine storm, and attribute many of the crisis’s fatalities to this rampant immune reaction. Emerging research suggests that assessment of interferon response, including blood levels of the cytokine IFN-α – which is considered to be one of the earliest indicators of dysregulation of the anti-viral immune response – IL-6 and several other inflammatory biomarkers are among the most promising prognostic markers for severe disease expression.
To further evaluate this theory, two research teams – one from the
As detailed in Science, the
“Like SARS and MERS before it, COVID-19 has proven capable of restricting the body’s natural response to a viral invasion. This can lead to a dysregulation of interferon and compromise the chain of immune response mechanisms that follow,” said
Although preliminary, the research demonstrates the potential utility of a test for type-I IFN deficiency in the blood to help stratify COVID-19 patients and support earlier intervention for those most likely to experience an acute reaction. Furthermore, findings from both studies offer new insights into the innate immune response and COVID-19 associated deficiencies that could inform ongoing therapeutic development and treatment decisions in clinical settings.
For more details about the scientific study led by the
For more details about the research projects of the
For more details on these studies and other Simoa-powered publications, visit: https://www.quanterix.com/resources/publications-posters.
Further details on Quanterix’ infectious disease offerings and educational resources, can be accessed here: https://www.quanterix.com/therapeutic-areas/infectious-disease.
For more information on
Details on the company’s homebrew services for developing customer Simoa assays are available here: https://www.quanterix.com/products-technology/homebrew.
COVID-19 investigators with questions about Simoa or who are in need of testing support are encouraged to contact our team at: https://www.quanterix.com/contact.
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